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KMID : 0374919920130010001
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Inje Medical Journal
1992 Volume.13 No. 1 p.1 ~ p.6
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Evaluation Laboratory Tests to Prevent Posttransfusion Hepatitis in Donated Blood
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Abstract
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Recently anti-HCV has become a routine serologic test for donor to prevent post-transfusion Non-A. Non-B hepatitis, but some author insisted that anti-HCV demonstrated an etiologic basis for only half of cases of transfusion associated Non-A,
Non-B
hepatitis.
This study was designed to evaluate the prevalence of each hepatitis marker and understand the correlation between serologic markers for hepatitis B and anti-HCV because it might be helful to understand association of each markers for effective
prevention of PTH.
1634 sera were collected from healthy blood donors in Sanggye and Seoul Paik Hospital and tested for BHsAg anti-HCV, ALT and anti-HBc and results were summarized as follows.
1. Seroprevalence of anti-HCV among blood donors was 0.49%.
2. The frequency of anti-HCV increased linearly with the increase of ALT value until 60IU/L (P<0.05), but ALT values of all anti-HCV positive donors were lower than 60IU/L.
3. HBsAg positive rate was 4.77% and ALT values were increased in 15.38% of HBsAg positive donors.
4. 2.33% of donors had increased ALT values above 60IU/L irrespective of HBaAg or anti-HCV.
5. Seroprevalence of anti-HBc was 54.1% among donors and correlation between anti-HBc and anti-HCV was not considered.
Above results revealed that the prevalence of anti-HCV was not higher than the one in western countries or Japan was HBsAg was the most prevalent hepatitis marker except anti-HBc still as expected. ALT couldn't become the important surrogate
marker
for
HCV in our country, but it would be necessary to study the increased ALT cases without other hepatitis markers to prevent PTII effectively.
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KEYWORD
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